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Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

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Abstract

The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.

Graphical abstract: Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

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Publication details

The article was received on 13 Sep 2017, accepted on 02 Nov 2017 and first published on 07 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC07173F
Citation: Chem. Commun., 2017, Advance Article
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    Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

    K. Betz, A. Nilforoushan, L. A. Wyss, K. Diederichs, S. J. Sturla and A. Marx, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07173F

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