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Regiocontrolled Direct C4 and C2-Methyl Thiolation of Indoles under Rhodium Catalyzed Mild Conditions

Abstract

A straightforward Rh(III)catalyzed general strategy was developed for the site selective remote C4 (sp2) and C2 (sp3)-methyl thiolation of indole core keeping the oxime directing group at the C3 position. The transformation was accomplished under mild conditions with wide scope and functional group tolerance. The directing group can easily be removed after operation. Methyl substitution at the C2 position of indole core led to C2 (sp3)-methyl thiolation.

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Publication details

The article was received on 10 Sep 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07086A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Regiocontrolled Direct C4 and C2-Methyl Thiolation of Indoles under Rhodium Catalyzed Mild Conditions

    S. Maity, U. Karmakar and R. Samanta, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC07086A

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