A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

Jing Wang; Min Pan; Jie Wei; Xiaoqing Liu; Fuan Wang

doi:10.1039/C7CC07057H

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A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays†

Jing Wang,^a Min Pan,^a Jie Wei,^a Xiaoqing Liu^a and Fuan Wang

*^a

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* Corresponding authors

^a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: fuanwang@whu.edu.cn
Fax: +86-27-68756307
Tel: +86-27-68756307

Abstract

An autonomous nonenzymatic DNA machine has been successfully engineered based on a two-layered cascaded hybridization chain reaction (C-HCR) circuit, in which the tandem outputs of the upstream HCR-1 unit activate the downstream HCR-2 unit to induce successive repeated hybridizations, generating branched DNA structures and enabling sensitive and selective detection of uracil-DNA glycosylase and its inhibitors.

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Article information

DOI: https://doi.org/10.1039/C7CC07057H
Article type: Communication
Submitted: 08 Sep 2017
Accepted: 09 Oct 2017
First published: 10 Oct 2017

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Chem. Commun., 2017,53, 12878-12881

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A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

J. Wang, M. Pan, J. Wei, X. Liu and F. Wang, Chem. Commun., 2017, 53, 12878 DOI: 10.1039/C7CC07057H

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Chemical Communications

A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays†

Abstract

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A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

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