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A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

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Abstract

An autonomous nonenzymatic DNA machine has been successfully engineered based on a two-layered cascaded hybridization chain reaction (C-HCR) circuit, in which the tandem outputs of the upstream HCR-1 unit activate the downstream HCR-2 unit to induce successive repeated hybridizations, generating branched DNA structures and enabling sensitive and selective detection of uracil-DNA glycosylase and its inhibitors.

Graphical abstract: A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

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Publication details

The article was received on 08 Sep 2017, accepted on 09 Oct 2017 and first published on 10 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07057H
Citation: Chem. Commun., 2017, Advance Article
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    A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

    J. Wang, M. Pan, J. Wei, X. Liu and F. Wang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07057H

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