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Nickel-Catalyzed Acetamidation and Lactamization of Arylboronic Acids

Abstract

Described is a nickel-catalyzed acetamidation and lactamization of arylboronic acids via one-pot reaction with ynamides and N-hydroxyphthalimide. The protocol is featured with mild reaction condition, broad substrate scope and successfully applied to late-stage functionalization of pharmaceuticals. Moreover, control reactions were conducted to elucidate a plausible mechanism.

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Publication details

The article was received on 08 Sep 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07055A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Nickel-Catalyzed Acetamidation and Lactamization of Arylboronic Acids

    B. Huang, L. Zeng, Y. Shen and S. Cui, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC07055A

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