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Nickel-catalyzed acetamidation and lactamization of arylboronic acids

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Abstract

A nickel-catalyzed acetamidation and lactamization of arylboronic acids via a one-pot reaction with ynamides and N-hydroxyphthalimide is described. This protocol features with mild reaction conditions and a broad substrate scope, and has been successfully applied to late-stage functionalization of pharmaceuticals. Moreover, control reactions were conducted to elucidate a plausible mechanism.

Graphical abstract: Nickel-catalyzed acetamidation and lactamization of arylboronic acids

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Publication details

The article was received on 08 Sep 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07055A
Citation: Chem. Commun., 2017, Advance Article
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    Nickel-catalyzed acetamidation and lactamization of arylboronic acids

    B. Huang, L. Zeng, Y. Shen and S. Cui, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC07055A

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