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Issue 92, 2017
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Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase

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Abstract

The synthesis of perdeuterated and 13C enriched myo-inositol is presented. Myo-inositol and its derivatives are of interest as substrates for enzymes producing phosphorylated species with regulatory functions in many organisms. Its utility in monitoring real-time phosphorylation by myo-inositol-3-kinase is illustrated using dynamic nuclear polarization (DNP) to enhance NMR observation.

Graphical abstract: Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase

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Publication details

The article was received on 07 Sep 2017, accepted on 18 Oct 2017 and first published on 18 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC07023C
Citation: Chem. Commun., 2017,53, 12398-12401
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    Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase

    M. J. Moure, Y. Zhuo, G. J. Boons and J. H. Prestegard, Chem. Commun., 2017, 53, 12398
    DOI: 10.1039/C7CC07023C

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