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Rhodium(III)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

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Abstract

A flexible and efficient rhodium(III)-catalyzed intramolecular annulation of benzamides bearing tethered alkynes for the synthesis of indolizinones and quinolizinones is reported. This reaction shows a broad substrate scope and excellent functional-group tolerance, including different kinds of heterocyclic substrates, such as furan, thiophene, pyrrole, benzofuran, benzothiophene, indole and isonicotinamide substrates. This method also provides a practical and efficient approach for the synthesis of rosettacin and oxypalmatime.

Graphical abstract: Rhodium(iii)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

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Publication details

The article was received on 01 Sep 2017, accepted on 21 Sep 2017 and first published on 21 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06860C
Citation: Chem. Commun., 2017, Advance Article
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    Rhodium(III)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

    L. Song, G. Tian, Y. He and E. V. Van der Eycken, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06860C

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