Issue 92, 2017

Rhodium(iii)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

Abstract

A flexible and efficient rhodium(III)-catalyzed intramolecular annulation of benzamides bearing tethered alkynes for the synthesis of indolizinones and quinolizinones is reported. This reaction shows a broad substrate scope and excellent functional-group tolerance, including different kinds of heterocyclic substrates, such as furan, thiophene, pyrrole, benzofuran, benzothiophene, indole and isonicotinamide substrates. This method also provides a practical and efficient approach for the synthesis of rosettacin and oxypalmatime.

Graphical abstract: Rhodium(iii)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2017
Accepted
21 Sep 2017
First published
21 Sep 2017

Chem. Commun., 2017,53, 12394-12397

Rhodium(III)-catalyzed intramolecular annulation through C–H activation: concise synthesis of rosettacin and oxypalmatime

L. Song, G. Tian, Y. He and E. V. Van der Eycken, Chem. Commun., 2017, 53, 12394 DOI: 10.1039/C7CC06860C

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