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Issue 86, 2017
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Novel activity-based probes for N-acylethanolamine acid amidase

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Abstract

The cysteine hydrolase, N-acylethanolamine acid amidase (NAAA) is a promising target for analgesic and anti-inflammatory drugs. Here, we describe the development of two unprecedented NAAA-reactive activity-based probes as research tools for application in the discovery of new inhibitors and for the in-depth characterization of NAAA in its cellular environment.

Graphical abstract: Novel activity-based probes for N-acylethanolamine acid amidase

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Publication details

The article was received on 31 Aug 2017, accepted on 09 Oct 2017 and first published on 10 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06838G
Citation: Chem. Commun., 2017,53, 11810-11813
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    Novel activity-based probes for N-acylethanolamine acid amidase

    R. Petracca, E. Romeo, M. P. Baggelaar, M. Artola, S. Pontis, S. Ponzano, H. S. Overkleeft, M. van der Stelt and D. Piomelli, Chem. Commun., 2017, 53, 11810
    DOI: 10.1039/C7CC06838G

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