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Issue 83, 2017
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Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification

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Abstract

We develop an antibody-free fluorescence method for the epidermal growth factor receptor (EGFR) assay using aptamer-based target-/probe-mediated cyclic signal amplification. The method is highly sensitive with a detection limit of 0.16 fM, and it can be applied to detect EGFR in lung cancer cells, holding great potential in clinical diagnosis.

Graphical abstract: Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification

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Publication details

The article was received on 31 Aug 2017, accepted on 29 Sep 2017 and first published on 29 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06823A
Citation: Chem. Commun., 2017,53, 11496-11499
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    Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification

    D. Zhang, F. Ma, Q. Zhang and C. Zhang, Chem. Commun., 2017, 53, 11496
    DOI: 10.1039/C7CC06823A

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