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Cysteine and glutathione trigger the Cu–Zn swap between Cu(II)-amyloid-β4-16 peptide and Zn7-metallothionein-3

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Abstract

Cysteine and glutathione are able to reduce Cu(II) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(I) to partially replace Zn(II) in the protein Zn7-metallothionein-3. The released Zn(II) in turn binds to amyloid-β4-16. Thus cysteine and glutathione are modulators of Cu/Zn-distribution between metallothionein-3 and amyloid-β4-16.

Graphical abstract: Cysteine and glutathione trigger the Cu–Zn swap between Cu(ii)-amyloid-β4-16 peptide and Zn7-metallothionein-3

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Publication details

The article was received on 31 Aug 2017, accepted on 21 Sep 2017 and first published on 21 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06802F
Citation: Chem. Commun., 2017, Advance Article
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    Cysteine and glutathione trigger the Cu–Zn swap between Cu(II)-amyloid-β4-16 peptide and Zn7-metallothionein-3

    A. Santoro, N. Ewa Wezynfeld, M. Vašák, W. Bal and P. Faller, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06802F

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