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Issue 83, 2017
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A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

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Abstract

Five unimolecular channels with different lengths are presented. The varying length of these channels has significant impact on their transmembrane transport properties, which are directly correlated with their antimicrobial activity and inversely correlated with their haemolytic toxicity. By further structural optimization, these new channels could reach high antimicrobial activity and very low haemolytic toxicity, with the potential to serve as systemic antibiotics.

Graphical abstract: A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

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Publication details

The article was received on 26 Aug 2017, accepted on 29 Sep 2017 and first published on 02 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06697J
Citation: Chem. Commun., 2017,53, 11492-11495
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    A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

    P. Xin, Y. Sun, H. Kong, Y. Wang, S. Tan, J. Guo, T. Jiang, W. Dong and C. Chen, Chem. Commun., 2017, 53, 11492
    DOI: 10.1039/C7CC06697J

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