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A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

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Abstract

To achieve a microarray universal to any SNP, we proposed a new way to construct a genotyping–microarray by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from invasive reactions on a slide surface. Our proposed microarray is labor-saving and cost-saving in setting up a new experiment for genotyping multiple SNPs, which is related to personalized medicine.

Graphical abstract: A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

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Publication details

The article was received on 24 Aug 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC06649J
Citation: Chem. Commun., 2017, Advance Article
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    A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

    Z. Chen, L. Miao, Y. Liu, T. Dong, X. Ma, X. Guan, G. Zhou and B. Zou, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06649J

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