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A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale

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Abstract

A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1–0.05 mol%) on a preparative scale (5–50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.

Graphical abstract: A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale

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Publication details

The article was received on 17 Aug 2017, accepted on 09 Nov 2017 and first published on 09 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC06468C
Citation: Chem. Commun., 2017, Advance Article
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    A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale

    S. Zhang, P. Deng, J. Zhou, M. Liu, G. Liang, Y. Xiong and H. Zhou, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06468C

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