Jump to main content
Jump to site search


Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Author affiliations

Abstract

Conformationally mobile oligomers with helical structures, or ‘dynamic foldamers’, may populate a mixture of screw-sense conformers whose relative proportion has been used as a means of communicating information on a molecular scale. The dibenzazepinyl urea provides a means of quantifying both the sense and degree of this screw-sense preference through a combination of circular dichroism (CD) and NMR spectroscopy. The dibenzazepinyl urea probe is synthetically versatile, readily accessible, and easy to introduce to the terminus of an amide or a urea foldamer.

Graphical abstract: Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Aug 2017, accepted on 31 Aug 2017 and first published on 31 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC06427F
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

    V. Diemer, J. Maury, B. A. F. Le Bailly, S. J. Webb and J. Clayden, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06427F

Search articles by author

Spotlight

Advertisements