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Issue 89, 2017
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Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

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Abstract

A thermo-responsive end-cap based on a retro-Diels–Alder and subsequent furan elimination reaction was developed. It was used to cap poly(ethyl glyoxylate), allowing end-to-end depolymerization upon thermal triggering. Using block copolymers, thermo-responsive micelles and vesicles were prepared and shown to disassemble upon heating. Thermal degradation could also be triggered indirectly by magnetic field hyperthermia after incorporation of iron oxide nanoparticles into the assemblies.

Graphical abstract: Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

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Publication details

The article was received on 16 Aug 2017, accepted on 05 Oct 2017 and first published on 06 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06410A
Citation: Chem. Commun., 2017,53, 12068-12071
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    Thermo-responsive self-immolative nanoassemblies: direct and indirect triggering

    B. Fan, J. F. Trant, G. Hemery, O. Sandre and E. R. Gillies, Chem. Commun., 2017, 53, 12068
    DOI: 10.1039/C7CC06410A

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