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Issue 78, 2017
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Polymer nanodiscs and macro-nanodiscs of a varying lipid composition

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Abstract

Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.

Graphical abstract: Polymer nanodiscs and macro-nanodiscs of a varying lipid composition

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Publication details

The article was received on 16 Aug 2017, accepted on 11 Sep 2017 and first published on 11 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06409H
Citation: Chem. Commun., 2017,53, 10824-10826
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    Polymer nanodiscs and macro-nanodiscs of a varying lipid composition

    V. S. K. Ramadugu, G. M. Di Mauro, T. Ravula and A. Ramamoorthy, Chem. Commun., 2017, 53, 10824
    DOI: 10.1039/C7CC06409H

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