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Issue 76, 2017
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Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2

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Abstract

Using amphiphilic cyclodextrin as a scaffold, the first class of PK-glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported. The generated glycomicroarray effectively mimics the plasma membrane surface while discriminating binding of the two Stx toxins, with unprecedented affinity to Stx2.

Graphical abstract: Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2

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Publication details

The article was received on 11 Aug 2017, accepted on 30 Aug 2017 and first published on 31 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC06299K
Citation: Chem. Commun., 2017,53, 10528-10531
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    Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2

    P. Zhang, E. Paszkiewicz, Q. Wang, J. M. Sadowska, P. I. Kitov, D. R. Bundle and C. Ling, Chem. Commun., 2017, 53, 10528
    DOI: 10.1039/C7CC06299K

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