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Issue 76, 2017
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Sensitive detection of microRNAs by duplex specific nuclease-assisted target recycling and pyrene excimer switching

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Abstract

Herein, we develop a simple fluorescence method for the sensitive detection of microRNAs based on duplex specific nuclease-assisted target recycling and pyrene excimer switching. This method is extremely sensitive with a detection limit of 0.58 fM, and it can be applied to absolutely detect endogenous microRNAs in cancer cells, holding great potential for clinical diagnosis and biomedical research studies.

Graphical abstract: Sensitive detection of microRNAs by duplex specific nuclease-assisted target recycling and pyrene excimer switching

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Publication details

The article was received on 11 Aug 2017, accepted on 05 Sep 2017 and first published on 05 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06290G
Citation: Chem. Commun., 2017,53, 10596-10599
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    Sensitive detection of microRNAs by duplex specific nuclease-assisted target recycling and pyrene excimer switching

    F. Ma, W. Liu, Q. Zhang and C. Zhang, Chem. Commun., 2017, 53, 10596
    DOI: 10.1039/C7CC06290G

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