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Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

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Abstract

Single-electron reduction of C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds of aldehydes, ketones, and imines results in the formation of ketyl and α-aminoalkyl anion radicals, respectively. These reactive intermediates are characterized by an altered electronic character with respect to their parent molecules and undergo a diverse range of synthetically useful transformations, which are not available to even-electron species. This Review summarizes the reactions of ketyl and α-aminyl radicals generated from carbonyl derivatives under transition-metal photoredox-catalysed conditions. We primarily focus on recent developments in the field, as well as give a brief overview of catalytic enantioselective transformations that provide a means to achieve precise stereocontrol over the reactivity of ion radicals.

Graphical abstract: Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

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Publication details

The article was received on 10 Aug 2017, accepted on 30 Oct 2017 and first published on 10 Nov 2017


Article type: Feature Article
DOI: 10.1039/C7CC06287G
Citation: Chem. Commun., 2017, Advance Article
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    Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

    K. N. Lee and M. Ngai, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06287G

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