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Issue 78, 2017
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Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation

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Abstract

A cascade approach has been developed towards dual C–C bond formation via consecutive C–H functionalization/cyclization giving access to pyrrolo[1,2-a]indoles in a highly regio- and diastereoselective manner using catalytic [Ru(p-cymene)Cl2]2. The methodology was further expanded to attain pentacyclic structures involving manifold C–C bond creation.

Graphical abstract: Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation

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Publication details

The article was received on 10 Aug 2017, accepted on 08 Sep 2017 and first published on 11 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06276A
Citation: Chem. Commun., 2017,53, 10812-10815
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    Ruthenium-catalysed one-pot regio- and diastereoselective synthesis of pyrrolo[1,2-a]indoles via cascade C–H functionalization/annulation

    S. Singh, H. H. Butani, D. D. Vachhani, A. Shah and E. V. Van der Eycken, Chem. Commun., 2017, 53, 10812
    DOI: 10.1039/C7CC06276A

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