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Issue 85, 2017
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An Ir-photoredox-catalyzed decarboxylative Michael addition of glyoxylic acid acetal as a formyl equivalent

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Abstract

We reported herein an iridium-photoredox-catalyzed decarboxylative conjugated addition of glyoxylic acid acetals with various Michael acceptors, including unsaturated amide, ester, aldehyde, ketone, and nitrile under irradiation. Vinyl pyridine and α-aryl styrene are also suitable substrates. The reaction offers various types of acetal products, which are of synthetic significance as protected aldehydes.

Graphical abstract: An Ir-photoredox-catalyzed decarboxylative Michael addition of glyoxylic acid acetal as a formyl equivalent

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Publication details

The article was received on 10 Aug 2017, accepted on 01 Oct 2017 and first published on 02 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06252D
Citation: Chem. Commun., 2017,53, 11642-11645
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    An Ir-photoredox-catalyzed decarboxylative Michael addition of glyoxylic acid acetal as a formyl equivalent

    S. Zhang, Z. Tan, H. Zhang, J. Liu, W. Xu and K. Xu, Chem. Commun., 2017, 53, 11642
    DOI: 10.1039/C7CC06252D

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