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Issue 75, 2017
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A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

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Abstract

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

Graphical abstract: A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

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Publication details

The article was received on 09 Aug 2017, accepted on 01 Sep 2017 and first published on 01 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06246J
Citation: Chem. Commun., 2017,53, 10406-10409
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    A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

    P. Guo, A. Paul, A. Kumar, N. K. Harika, S. Wang, A. A. Farahat, D. W. Boykin and W. D. Wilson, Chem. Commun., 2017, 53, 10406
    DOI: 10.1039/C7CC06246J

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