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Issue 80, 2017
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A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

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Abstract

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.

Graphical abstract: A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

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Publication details

The article was received on 09 Aug 2017, accepted on 23 Aug 2017 and first published on 24 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC06211G
Citation: Chem. Commun., 2017,53, 11008-11011
  • Open access: Creative Commons BY license
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    A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

    N. L. Sloan, S. K. Luthra, G. McRobbie, S. L. Pimlott and A. Sutherland, Chem. Commun., 2017, 53, 11008
    DOI: 10.1039/C7CC06211G

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