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Issue 75, 2017
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An approach to spirooxindoles via palladium-catalyzed remote C–H activation and dual alkylation with CH2Br2

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Abstract

A facile and efficient approach for the synthesis of spirooxindoles has been developed via the coupling of spirocyclic C,C-palladacycles with CH2Br2. The key spirocyclic palladacycles are generated catalytically via remote C–H activation. A range of spirooxindoles can be synthesized in good to excellent yields from readily available starting material.

Graphical abstract: An approach to spirooxindoles via palladium-catalyzed remote C–H activation and dual alkylation with CH2Br2

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Publication details

The article was received on 08 Aug 2017, accepted on 03 Sep 2017 and first published on 04 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06196J
Citation: Chem. Commun., 2017,53, 10429-10432
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    An approach to spirooxindoles via palladium-catalyzed remote C–H activation and dual alkylation with CH2Br2

    C. Shao, Z. Wu, X. Ji, B. Zhou and Y. Zhang, Chem. Commun., 2017, 53, 10429
    DOI: 10.1039/C7CC06196J

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