An approach to spirooxindoles via palladium-catalyzed remote C–H activation and dual alkylation with CH2Br2

Abstract

A facile and efficient approach for the synthesis of spirooxindoles has been developed via the coupling of spirocyclic C,C-palladacycles with CH₂Br₂. The key spirocyclic palladacycles are generated catalytically via remote C–H activation. A range of spirooxindoles can be synthesized in good to excellent yields from readily available starting material.