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Issue 79, 2017
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A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

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Abstract

A new class of easily available and readily tunable proline based chiral organocatalysts was found to efficiently catalyse an unprecedented highly enantioselective asymmetric Darzens reaction of α-chloroketones and substituted α-chloroketones with various aldehydes, which directly produces optically active di- and tri-substituted chiral epoxides with higher product yields (up to 97%) and excellent ee's (up to 99%) under mild reaction conditions.

Graphical abstract: A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

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Publication details

The article was received on 08 Aug 2017, accepted on 13 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06194C
Citation: Chem. Commun., 2017,53, 10926-10929
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    A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

    V. Ashokkumar, A. Siva and R. Ramaswamy Chidambaram, Chem. Commun., 2017, 53, 10926
    DOI: 10.1039/C7CC06194C

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