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Site-selective tagging of proteins by pnictogen-mediated self-assembly

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Abstract

Site-selective chemical protein modification is achieved by self-assembly of a specific di-cysteine motif, trivalent pnictogens (As, Sb or Bi) and an aromatic mercaptomethyl-based probe. The strategy is demonstrated with a quaternary complex involving Zika virus protease and a lanthanide ion, enabling paramagnetic nuclear magnetic resonance spectroscopy and luminescence measurements.

Graphical abstract: Site-selective tagging of proteins by pnictogen-mediated self-assembly

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Publication details

The article was received on 07 Aug 2017, accepted on 05 Sep 2017 and first published on 05 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06155B
Citation: Chem. Commun., 2017, Advance Article
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    Site-selective tagging of proteins by pnictogen-mediated self-assembly

    C. Nitsche, M. C. Mahawaththa, W. Becker, T. Huber and G. Otting, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06155B

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