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Programmable fusion of liposomes mediated by lipidated PNA

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Abstract

We recently reported a DNA-programmed fusion cascade enabling the use of liposomes as nanoreactors for compartmentalized chemical reactions. This communication reports an alternative and robust strategy based on lipidated peptide nucleic acids (LiPs). LiPs enabled fusion of liposomes with remarkable 31% efficiency at 50 °C with low leakage (5%).

Graphical abstract: Programmable fusion of liposomes mediated by lipidated PNA

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Publication details

The article was received on 03 Aug 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06058K
Citation: Chem. Commun., 2017, Advance Article
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    Programmable fusion of liposomes mediated by lipidated PNA

    A. Rabe, P. M. G. Löffler, O. Ries and S. Vogel, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06058K

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