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Issue 83, 2017
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A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

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Abstract

By functionalizing triarylboron with cyclen, we developed a two-photon fluorescence probe, TAB-2, which can selectively bind RNA with a ratiometric readout. We tested TAB-2 in NIH/3T3 fibroblast cells, and demonstrated its capability in visualizing nucleoli and analyzing microenvironment polarity by two-photon and fluorescence-lifetime imaging microscopy.

Graphical abstract: A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

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Publication details

The article was received on 02 Aug 2017, accepted on 02 Oct 2017 and first published on 02 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC06045A
Citation: Chem. Commun., 2017,53, 11476-11479
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    A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

    J. Liu, S. Zhang, C. Zhang, J. Dong, C. Shen, J. Zhu, H. Xu, M. Fu, G. Yang and X. Zhang, Chem. Commun., 2017, 53, 11476
    DOI: 10.1039/C7CC06045A

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