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Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

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Abstract

Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.

Graphical abstract: Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

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Publication details

The article was received on 01 Aug 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC06010F
Citation: Chem. Commun., 2017, Advance Article
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    Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

    D. E. Crawford, C. K. Miskimmin, J. Cahir and S. L. James, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC06010F

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