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Issue 92, 2017
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Single-step synthesis of styryl phosphonic acids via palladium-catalyzed Heck coupling of vinyl phosphonic acid with aryl halides

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Abstract

We have developed a single step palladium-catalyzed Heck coupling of aryl halides with vinyl phosphonic acid to produce functionalized (E)-styryl phosphonic acids. This pathway utilizes a variety of commercially available aryl halides, vinyl phosphonic acid and Pd(P(tBu)3)2 as catalyst. These conditions produce a wide range of styryl phosphonic acids with high purities and good to excellent yields (31–80%).

Graphical abstract: Single-step synthesis of styryl phosphonic acids via palladium-catalyzed Heck coupling of vinyl phosphonic acid with aryl halides

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Publication details

The article was received on 28 Jul 2017, accepted on 22 Oct 2017 and first published on 27 Oct 2017


Article type: Communication
DOI: 10.1039/C7CC05909D
Citation: Chem. Commun., 2017,53, 12454-12456
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    Single-step synthesis of styryl phosphonic acids via palladium-catalyzed Heck coupling of vinyl phosphonic acid with aryl halides

    B. W. McNichols, J. T. Koubek and A. Sellinger, Chem. Commun., 2017, 53, 12454
    DOI: 10.1039/C7CC05909D

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