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Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

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Abstract

The widely existing transmembrane helices can serve as a novel type of binding site for recognizing corresponding membrane receptors. Through imprinting the transmembrane domain of certain receptors, here we report the construction of polymeric nanoparticles which can achieve enhanced cellular uptake and permeability in target tissues for tumor-targeted drug delivery.

Graphical abstract: Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

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Publication details

The article was received on 28 Jul 2017, accepted on 11 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05894B
Citation: Chem. Commun., 2017, Advance Article
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    Enhanced cellular uptake and tumor penetration of nanoparticles by imprinting the “hidden” part of membrane receptors for targeted drug delivery

    S. Peng, Y. Wang, N. Li and C. Li, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC05894B

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