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Issue 75, 2017
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Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

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Abstract

Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C–H fluorination.

Graphical abstract: Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

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Publication details

The article was received on 25 Jul 2017, accepted on 29 Aug 2017 and first published on 29 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05794F
Citation: Chem. Commun., 2017,53, 10394-10397
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    Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

    J. B. Lee, M. E. Kang, J. Kim, C. Y. Lee, J. Kee, K. Myung, J. Park and S. Y. Hong, Chem. Commun., 2017, 53, 10394
    DOI: 10.1039/C7CC05794F

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