Jump to main content
Jump to site search

Issue 75, 2017
Previous Article Next Article

Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from N-propargylamides

Author affiliations

Abstract

Novel catalytic systems consisting of cationic gold complexes, N-hydroxyphthalimide (NHPI), and transition-metal-based Lewis acids have been developed for the one-pot synthesis of functionalized oxazoles from N-propargylamides with excellent functional group tolerance. These transformations demonstrated the excellent compatibility of homogeneous gold catalysis with organocatalytic oxidative carbon–nitrogen bond formations using tert-butyl nitrite as the terminal oxidant. Moreover, oxazolecarbonitriles or carboxamides can be easily synthesized in a one-pot protocol according to the different synthetic requirements.

Graphical abstract: Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from N-propargylamides

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jul 2017, accepted on 21 Aug 2017 and first published on 21 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05746F
Citation: Chem. Commun., 2017,53, 10366-10369
  •   Request permissions

    Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from N-propargylamides

    S. Mai, C. Rao, M. Chen, J. Su, J. Du and Q. Song, Chem. Commun., 2017, 53, 10366
    DOI: 10.1039/C7CC05746F

Search articles by author

Spotlight

Advertisements