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Issue 76, 2017
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Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

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Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA–protein interactions triggered by the PS2 moiety.

Graphical abstract: Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

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Publication details

The article was received on 23 Jul 2017, accepted on 28 Aug 2017 and first published on 29 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05722A
Citation: Chem. Commun., 2017,53, 10508-10511
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    Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

    X. Yang, N. Dinuka Abeydeera, F. Liu and M. Egli, Chem. Commun., 2017, 53, 10508
    DOI: 10.1039/C7CC05722A

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