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Issue 84, 2017
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Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

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Abstract

G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide sequence drastically increases the probability of forming tetramolecular parallel G4s with unprecedented conformational control over other unspecific oligomers or folds.

Graphical abstract: Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

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Publication details

The article was received on 29 Jul 2017, accepted on 29 Sep 2017 and first published on 29 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05693A
Citation: Chem. Commun., 2017,53, 11560-11563
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    Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

    B. Vialet, A. Gissot, R. Delzor and P. Barthélémy, Chem. Commun., 2017, 53, 11560
    DOI: 10.1039/C7CC05693A

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