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Liposome-encoded magnetic beads initiated by padlock exponential rolling circle amplification for portable and accurate quantification of microRNAs

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Abstract

Development of reliable and affordable quantitative methods for miRNAs with high specificity and sensitivity is a central challenge to make miRNA testing a routine part of medical care with respect to cancer. Herein, we propose a strategy for glucoamylase-encapsulated liposome-encoded magnetic beads initiated by padlock exponential rolling circle amplification (P-ERCA) for portable and accurate quantification of miRNA by using a glucometer readout.

Graphical abstract: Liposome-encoded magnetic beads initiated by padlock exponential rolling circle amplification for portable and accurate quantification of microRNAs

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Publication details

The article was received on 24 Jul 2017, accepted on 23 Aug 2017 and first published on 23 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05686A
Citation: Chem. Commun., 2017, Advance Article
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    Liposome-encoded magnetic beads initiated by padlock exponential rolling circle amplification for portable and accurate quantification of microRNAs

    Q. Xue, Y. Kong, H. Wang and W. Jiang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC05686A

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