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Issue 75, 2017
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Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

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Abstract

β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.

Graphical abstract: Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

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Publication details

The article was received on 19 Jul 2017, accepted on 30 Aug 2017 and first published on 30 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05604D
Citation: Chem. Commun., 2017,53, 10448-10451
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    Ruthenium catalyzed β-C(sp3)–H functionalization on the ‘privileged’ piperazine nucleus

    V. Murugesh, C. Bruneau, M. Achard, A. R. Sahoo, G. V. M. Sharma and S. Suresh, Chem. Commun., 2017, 53, 10448
    DOI: 10.1039/C7CC05604D

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