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Issue 77, 2017
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Synergistic silver/scandium catalysis for divergent synthesis of skeletally diverse chromene derivatives

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Abstract

The combination of AgTFA and Sc(OTf)3 enables the bimetallic synergistic catalysis of β-alkynyl ketones and o-hydroxybenzyl alcohols, allowing divergent synthesis of three classes of skeletally diverse chromene derivatives with generally good yields and high diastereoselectivity through dehydroxylated bi- and tri-cyclization cascades. The selectivity of these cycloadditions was controlled by adjusting the catalyst loading and reaction temperatures. The mechanisms for forming these compounds were proposed.

Graphical abstract: Synergistic silver/scandium catalysis for divergent synthesis of skeletally diverse chromene derivatives

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Publication details

The article was received on 18 Jul 2017, accepted on 07 Sep 2017 and first published on 07 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05563C
Citation: Chem. Commun., 2017,53, 10692-10695
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    Synergistic silver/scandium catalysis for divergent synthesis of skeletally diverse chromene derivatives

    S. Liu, K. Chen, X. Lan, W. Hao, G. Li, S. Tu and B. Jiang, Chem. Commun., 2017, 53, 10692
    DOI: 10.1039/C7CC05563C

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