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Single Quantum Dot-Based Nanosensor for Rapid and Sensitive Detection of Terminal Deoxynucleotidyl Transferase

Abstract

We develop a simple and rapid method for terminal deoxynucleotidyl transferase (TdT) assay on the basis of polymerization-directed exonuclease-assisted construction of single quantum dot (QD)-based fluorescence resonance energy transfer (FRET) nanosensor. This method is very sensitive with a detection limit of as low as 1 × 10-6 U/μL, and it can be used for the screening of TDT inhibitors and accurate quantification of TdT activity even in 5 cancer cells.

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Publication details

The article was received on 15 Jul 2017, accepted on 14 Sep 2017 and first published on 14 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC05485H
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Single Quantum Dot-Based Nanosensor for Rapid and Sensitive Detection of Terminal Deoxynucleotidyl Transferase

    L. Wang, M. Luo, Q. Zhang, B. Tang and C. Zhang, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC05485H

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