Silver-mediated oxidative C–H difluoromethylation of phenanthridines and 1,10-phenanthrolines

Sheng-Qing Zhu; Xiu-Hua Xu; Feng-Ling Qing

doi:10.1039/C7CC05411D

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Silver-mediated oxidative C–H difluoromethylation of phenanthridines and 1,10-phenanthrolines†

Sheng-Qing Zhu,^a Xiu-Hua Xu^a and Feng-Ling Qing

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China
E-mail: flq@mail.sioc.ac.cn

^b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China

Abstract

A silver-mediated oxidative difluoromethylation of phenanthridines and 1,10-phenanthrolines with TMSCF₂H is disclosed. This C–H difluoromethylation of N-containing polycyclic aromatics constitutes an efficient method for the regioselective synthesis of difluoromethylated N-heterocycles.

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Article information

DOI: https://doi.org/10.1039/C7CC05411D
Article type: Communication
Submitted: 14 Jul 2017
Accepted: 01 Oct 2017
First published: 02 Oct 2017

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Chem. Commun., 2017,53, 11484-11487

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Silver-mediated oxidative C–H difluoromethylation of phenanthridines and 1,10-phenanthrolines

S. Zhu, X. Xu and F. Qing, Chem. Commun., 2017, 53, 11484 DOI: 10.1039/C7CC05411D

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Chemical Communications

Silver-mediated oxidative C–H difluoromethylation of phenanthridines and 1,10-phenanthrolines†

Abstract

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Article information

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Silver-mediated oxidative C–H difluoromethylation of phenanthridines and 1,10-phenanthrolines

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