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Issue 68, 2017
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Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution

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Abstract

The long-standing problem of achieving high activity of a thermophilic enzyme at low temperatures and short reaction times with little tradeoff in thermostability has been solved by directed evolution, an alcohol dehydrogenase found in hot springs serving as the catalyst in enantioselective ketone reductions.

Graphical abstract: Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution

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Publication details

The article was received on 13 Jul 2017, accepted on 01 Aug 2017 and first published on 04 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05377K
Citation: Chem. Commun., 2017,53, 9454-9457
  • Open access: Creative Commons BY license
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    Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution

    G. Li, M. A. Maria-Solano, A. Romero-Rivera, S. Osuna and M. T. Reetz, Chem. Commun., 2017, 53, 9454
    DOI: 10.1039/C7CC05377K

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