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Issue 70, 2017
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Controllable access to multi-substituted imidazoles via palladium(II)-catalyzed C–C coupling and C–N condensation cascade reactions

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Abstract

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C–C coupling followed by intramolecular C–N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield.

Graphical abstract: Controllable access to multi-substituted imidazoles via palladium(ii)-catalyzed C–C coupling and C–N condensation cascade reactions

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Publication details

The article was received on 10 Jul 2017, accepted on 08 Aug 2017 and first published on 08 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05315K
Citation: Chem. Commun., 2017,53, 9745-9748
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    Controllable access to multi-substituted imidazoles via palladium(II)-catalyzed C–C coupling and C–N condensation cascade reactions

    H. Yu, L. Xiao, X. Yang and L. Shao, Chem. Commun., 2017, 53, 9745
    DOI: 10.1039/C7CC05315K

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