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Issue 66, 2017
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Utilizing an iron(III)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria

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Abstract

A direct and selective method for the functionalization of aerobactin has been described. Selectivity was achieved by masking the functioning carboxylate via iron-chelation, leaving the two remaining carboxylates for direct modification. Both mono- and bis-functionalized aerobactin effectively targeted pathogenic bacteria, showing a facile method with prospective applications.

Graphical abstract: Utilizing an iron(iii)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria

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Publication details

The article was received on 05 Jul 2017, accepted on 26 Jul 2017 and first published on 26 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC05197B
Citation: Chem. Commun., 2017,53, 9265-9268
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    Utilizing an iron(III)-chelation masking strategy to prepare mono- and bis-functionalized aerobactin analogues for targeting pathogenic bacteria

    Y. Ho, S. Ho, C. Hsu, J. Shie and T. A. Wang, Chem. Commun., 2017, 53, 9265
    DOI: 10.1039/C7CC05197B

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