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Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

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Abstract

We have, for the first time, developed a near-infrared fluorescent probe for aminopeptidase N by combining a hemicyanine and an alanyl residue. The probe exhibits high selectivity and sensitivity with a detection limit of 0.8 ng mL−1. With the probe, aminopeptidase N has been imaged in both cells and mice in vivo, indicating a promising tool for studying the function of the enzyme.

Graphical abstract: Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

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Publication details

The article was received on 04 Jul 2017, accepted on 02 Aug 2017 and first published on 02 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05142E
Citation: Chem. Commun., 2017, Advance Article
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    Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

    X. He, Y. Hu, W. Shi, X. Li and H. Ma, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC05142E

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