SCHEDULED MAINTENANCE
A normal duplex holds as many Watson–Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.
M. Hornum, P. K. Sharma, C. Reslow-Jacobsen, P. Kumar, M. Petersen and P. Nielsen, Chem. Commun., 2017, 53, 9717 DOI: 10.1039/C7CC05047J
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