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One-pot borylation/Suzuki–Miyaura sp2–sp3 cross-coupling

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Abstract

We describe the first one-pot borylation/Suzuki–Miyaura sp2–sp3 cross-coupling between readily available aryl (pseudo)halides and activated alkyl chlorides. This method streamlines the synthesis of diaryl methanes, α-aryl carbonyls and allyl aryl compounds, substructures that are commonly found in life changing drug molecules.

Graphical abstract: One-pot borylation/Suzuki–Miyaura sp2–sp3 cross-coupling

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Publication details

The article was received on 29 Jun 2017, accepted on 01 Aug 2017 and first published on 02 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05037B
Citation: Chem. Commun., 2017, Advance Article
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    One-pot borylation/Suzuki–Miyaura sp2–sp3 cross-coupling

    L. Whitaker, H. Y. Harb and A. P. Pulis, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC05037B

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