One-pot borylation/Suzuki–Miyaura sp2–sp3 cross-coupling

Abstract

We describe the first one-pot borylation/Suzuki–Miyaura sp²–sp³ cross-coupling between readily available aryl (pseudo)halides and activated alkyl chlorides. This method streamlines the synthesis of diaryl methanes, α-aryl carbonyls and allyl aryl compounds, substructures that are commonly found in life changing drug molecules.