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Issue 60, 2017
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Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

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Abstract

Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases. Despite their potential therapeutic value, there are no suitably protected ALE building blocks reported in the literature to enable their site-specific incorporation into synthetic peptides. The synthesis of an Fmoc-protected ALE building block, Nāˆˆ-(3-methylpyridinium)lysine (MP-lysine) and its incorporation into collagen model peptides is reported.

Graphical abstract: Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

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Publication details

The article was received on 29 Jun 2017, accepted on 06 Jul 2017 and first published on 06 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC05025A
Citation: Chem. Commun., 2017,53, 8459-8462
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    Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides

    I. Kavianinia, S. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks and M. A. Brimble, Chem. Commun., 2017, 53, 8459
    DOI: 10.1039/C7CC05025A

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