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One Step Synthesis of γ-Alkylidenebutenolides from Simple Vinyl Carboxylic Acids and Alkenes

Abstract

The first tandem cross-coupling/oxa-Michael addition/ dehydrogenation process by rhodium chemistry is described, which provides a straightforward and atom-economical protocol for the synthesis of a wide range of valuable γ-alkylidenebutenolides. This method is of particular interest because of employing widely available and low cost vinyl carboxylic acids and electron-deficient alkenes as building blocks. Moreover, the methodology can be applied to a gram scale synthesis with 1 mol% catalyst loading.

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Publication details

The article was received on 27 Jun 2017, accepted on 11 Aug 2017 and first published on 11 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC04973K
Citation: Chem. Commun., 2017, Accepted Manuscript
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    One Step Synthesis of γ-Alkylidenebutenolides from Simple Vinyl Carboxylic Acids and Alkenes

    J. Zhang, G. Zhong and C. Yu, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC04973K

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